The impairment of HMGB1 function results in improved mitochondrial DNA destruction. In the SCA1 mouse model, more than-expression in the HMGB1 protein via an introduced virus vector bearing the HMGB1 gene facilitates repair from the mitochondrial DNA injury, ameliorates the neuropathology as well as motor deficits, and extends the lifespan https://sw03329111097.worldblogged.com/34141624/the-definitive-guide-to-seltorexant