Schematic representation of activated and inhibited Wnt/β-catenin pathway. “WNT ON condition�? On ligation of Wnts to their receptors made up of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates in the nucleus and binds to TCF/LEF transcription components https://johnl308zei1.blog-a-story.com/profile