Gastrointestinal (GI): NSAIDs that block COX-1 action have correlations with GI issues due to the inhibition with the synthesis of gastroprotective agents for instance PGE2 as well as other prostaglandins. This inhibition brings about lowered mucin generation by gastric epithelial cells, significantly less bicarbonate secretion, and fewer epithelial mobile turnover, https://winstonh913kfy3.wikikarts.com/user