Investigation into conolidine has led to discovery of the opioid receptor in the body named ACKR3/CXCR7. ACKR3 is apparently essentially the most sought after target for conolidine, which also disregards the other 4 classical opioid receptors(3). There's curiosity in using conolidine as being a pain-reliever according to proof from https://travisktwux.timeblog.net/74619583/a-review-of-alternative-natural-pain-relief-to-replace-traditional-painkillers